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Research

Higher eukaryotes have larger genomes but not, proportionately, more number of genes. It is, therefore, more sophisticated regulation of genes, and not the number of genes, that has contributed to the evolution of complexity.

Our lab is interested in understanding how information is encoded in genomes and expressed in regulated manner during development and its interaction with the environment. We explore regulation of genes in the context of genome organization that involves higher order chromatin structure and epigenetic mechanisms; under the following three major themes:
  • Packaging of genome into cell type specific epigenomes

    Packaging of genome into cell type specific epigenomes

    Packaging of genome into cell type specific epigenomes
  • Hox gene complexes

    Hox gene complexes

    Hox gene complexes : epigenetic regulation and evolution of complexity
  • Nuclear architecture and the structural basis of epigenetic cellular memory

    Nuclear architecture and the structural basis of epigenetic cellular memory

    Nuclear architecture and the structural basis of epigenetic cellular memory

"The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity." – Albert Einstein

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