23 Nov 2020

Oded Rechavi

C.elegans Parental Experiences Regulate a Critical Decision Made by the Progeny

C. elegans can transmit certain responses transgenerationally, however it is unknown whether these can impact the process of evolution. Here, by studying nematodes that choose whether to self-reproduc...

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16 Oct 2020

Siddhesh Kamat

A chemical biology approach towards understanding a human neurological disorder

Polyneuropathy, Hearing loss, Ataxia, Retinitis pigmentosa, and Cataract (PHARC) is an autosomal recessive human genetic neurological disorder caused by deleterious (null) mutations to the abhd12 gene...

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18 Sep 2020

Madeline Lancaster

Examining human brain structure and function with cerebral organoids

The human brain exhibits a number of unique characteristics, such as dramatic size expansion and variation in relative abundance of specific neuron populations. In an effort to better understand human...

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10 Aug 2020

Steven Henikoff

Genome-wide mapping of protein-DNA interaction dynamics

We recently introduced new tools for high-resolution genome-wide chromatin profiling and have applied them to study chromatin organization and dynamics in a variety of model systems, including yeast, ...

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09 Jul 2020

Grant Jensen

Electron cryotomography and the ultrastructure of cells

In the last ten years electron cryotomography (cryo-ET) has made it possible to visualize large macromolecular assemblies inside intact cells in a near-native, "frozen-hydrated" state in 3-D to a few ...

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