CCMB
Research @ BIC

Research Links

Overview of Research Areas

  1. Genome organization and epigenetic regulation
  2. Theoretical studies of biological systems
    • Analysis of protein structure and function using Protein Contact Networks.
    • Development of simple and computationally inexpensive alignment-free methods for classification based on genomic heterogeneity using Chaos Game Representation and Multi-fractal analysis.
    • Studying host-parasite co-evolution using genome sequence analysis of HIV-1.
    • Comparative genomic analysis of evolution of metabolic pathways and horizontal gene transfer in prokaryotes.
    • Modelling feedback regulatory processes in biochemical pathways using "gene circuits", and the dynamical effects of noise.
    • Large scale reconstruction and analysis of metabolic pathways using graph theory and optimisation techniques in health and disease.
    • Understanding collective behaviour in multi-cell systems using physical principles.
    • Studying disease prevalence in populations using mathematical and statistical modelling.
  3. Homology modeling of serotonin receptor
  4. Affibody engineered for cell-specific nucleic acid targeting
  5. Structural bioinformatics
    • Towards understanding the mechanism of Type III Polyketide Synthases.
    • Bioinformatics of proteins involved in lipid metabolism in Mycobacterium tuberculosis.
    • Bioinformatic Studies on a Unique Cell Wall-Degrading Esterase.
    • Bioinformatic analysis on archael tRNA synthetases.
  6. Sequence-Structure Relatedness in Proteins
    • Protein Sequence-Structure Analysis Relational Database.
    • Conformations of Hexapeptide and Large Continuous Single Amino Acid Repeats in Proteins.
    • Certain Heptapeptide and Large Chameleon Sequences in Proteins.
    • Amino Acid Periodicity Peptides in Proteins.
    • Disulphide Bridged Connectivity Patterns in Proteins.
    • Analysis and the Conformations of Short Intra-Chain Disulphide Bridged Peptides in Proteins.
    • Heteroatom Groups and their Neighbors in Proteins.
    • Analysis, Detection and the Prediction of Structural Motifs in Proteins.
    • Database of Structural Motifs in Proteins.
  7. Protein Three-dimensional Models
    • Plasmepsin V of Plasmodium falciparum.
    • IspC protein coding genes from the genomes representing bacterial sub-groups.
    • Corynemycolyltransferases in C.glutamicum and C.efficiens.
    • C-terminal domain of human alpha-A and alpha-B crystallins.
  8. Functional Genomics